Definition: something that causes great unhappiness
Usage: her death was a great grief to John
Similar words: negative stimulus
Definition: a stimulus with undesirable consequences
Synonyms: brokenheartedness, heartache, heartbreak, grief
Definition: intense sorrow caused by loss of a loved one (especially by death)
Similar words: sorrow
Definition: an emotion of great sadness associated with loss or bereavement
Usage: he tried to express his sorrow at her loss