Synonyms: aggravation, exacerbation
Definition: action that makes a problem or a disease (or its symptoms) worse
Usage: the aggravation of her condition resulted from lack of care
Similar words: intensification
Definition: action that makes something stronger or more extreme
Synonyms: exacerbation
Definition: violent and bitter exasperation
Usage: his foolishness was followed by an exacerbation of their quarrel
Similar words: exasperation
Definition: actions that cause great irritation (or even anger)