Definition: something that causes irritation and annoyance
Usage: he's a thorn in my flesh
Similar words: bother, botheration, pain, pain in the ass, pain in the neck, annoyance, infliction
Definition: something or someone that causes trouble; a source of unhappiness
Usage: washing dishes was a nuisance before we got a dish washer; a bit of a bother; he's not a friend, he's an infliction